We defined a relationship between a gene and drug broadly. We accepted as relationships phenomena including physical interactions (such as metabolism) between the gene and drug, correlations between gene and drug activity, or clinical significance or toxicity associated with gene or drug levels. We annotated three types of relationships:
# Citations is the number of MEDLINE citations in which the gene and drug occurred (in our MEDLINE 2001 database). Relationship is described above. PMID is the PubMed ID that gives evidence of the relationship, if any.
The data is also available in Microsoft Excel format (19Kb download).
| Gene | Drug | # Citations | Relationship | PMID |
|---|---|---|---|---|
| Aldehyde dehydrogenase | Ethanol | 291 | Related | 11762132 |
| Glutathione S-transferase | Glutathione | 277 | Related | 345769 |
| Angiotensin-converting enzyme | Insulin | 178 | Related | 2220797 |
| Glucocorticoid receptor | Steroids | 165 | Related | 366226 |
| CYP1A1 | Ethoxyresorufin | 151 | Related | 6422171 |
| CYP2D6 | Quinidine | 145 | Related | 12867484 |
| CYP2D6 | Mephenytoin | 115 | Related | 8861658 |
| Angiotensin-converting enzyme | Beta blockers | 109 | Related | 191300 |
| Angiotensin-converting enzyme | Hydralazine | 88 | Related | 2416221 |
| CYP3A4 | Mephenytoin | 84 | Related | 8861658 |
| CYP1A2 | Mephenytoin | 82 | Related | 8861658 |
| CYP2C9 | Mephenytoin | 81 | Related | 8861658 |
| Angiotensin-converting enzyme | Propranolol | 78 | Related | 2531184 |
| MRP | Conjugates | 76 | Not Related | |
| Angiotensin-II receptor | Enalapril | 75 | Related | 10076917 |
| Alcohol dehydrogenase | Glutathione | 73 | Related | 12631283 |
| Angiotensin-II receptor | Captopril | 68 | Related | 10052650 |
| Angiotensin-converting enzyme | Calcium channel blockers | 65 | Related | 2487803 |
| CYP1A2 | Phenacetin | 61 | Related | 7678502 |
| CYP1A2 | Quinidine | 60 | Related | 7895609 |
| CYP2E1 | Glutathione | 60 | Related | 9101035 |
| CYP3A4 | Dextromethorphan | 60 | Related | 9352574 |
| Angiotensin-converting enzyme | Digoxin | 58 | Related | 7503006 |
| CYP1A2 | Benzo(a)pyrene | 57 | Related | 8819302 |
| CYP1A2 | Dextromethorphan | 57 | Related | 9352574 |
| CYP1A2 | Tolbutamide | 56 | Related | 9431831 |
| CYP3A4 | Tolbutamide | 56 | Related | 9431831 |
| CYP2D6 | Tolbutamide | 55 | Related | 9431831 |
| CYP2E1 | Mephenytoin | 55 | Related | 11523064 |
| DT-diaphorase | Glutathione | 55 | Related | 2391358 |
| CYP2C9 | Quinidine | 54 | Related | 7720520 |
| CYP2D6 | Fluvoxamine | 54 | Related | 8846617 |
| CYP2E1 | Ethoxyresorufin | 53 | Related | 10383922 |
| CYP2C19 | Tolbutamide | 51 | Related | 10411572 |
| CYP2C19 | Dextromethorphan | 50 | Related | 10859141 |
| CYP2C9 | Dextromethorphan | 50 | Related | 10859141 |
| CYP2D6 | Caffeine | 50 | Related | 9867310 |
| Glucocorticoid receptor | Insulin | 50 | Related | 12351458 |
| MDR1 | Glutathione | 50 | Related | 1348425 |
| CYP2D6 | Coumarin | 49 | Related | 10828259 |
| CYP2E1 | Coumarin | 49 | Related | 10828259 |
| CYP1A2 | Coumarin | 47 | Related | 10828259 |
| CYP3A4 | Coumarin | 46 | Related | 10828259 |
| CYP2C19 | Quinidine | 44 | Related | 7640150 |
| ALDH2 | Ethanol | 43 | Related | 3067025 |
| Catechol-O-methyltransferase | Dopamine | 42 | Related | 8190296 |
| CYP3A4 | Ethoxyresorufin | 42 | Related | 10725303 |
| CYP1A1 | Glutathione | 41 | Related | 12519694 |
| CYP1A2 | Glutathione | 41 | Not Related | 11714871 |
| CYP2C19 | Fluvoxamine | 41 | Related | 10674711 |
| ALDH2 | Glutathione | 1 | No Evidence | |
| Angiotensin-II receptor | Androgens | 1 | No Evidence | |
| CYP1A1 | Fluorouracil | 1 | No Evidence | |
| CYP1A1 | Lidocaine | 1 | No Evidence | |
| CYP1A1 | Lovastatin | 1 | Not Related | 11523064 |
| CYP1A2 | Histamine | 1 | Related | 9485522 |
| CYP1A2 | Macrolides | 1 | Related | 8119047 |
| CYP1B1 | Omeprazole | 1 | No Evidence | |
| CYP1B1 | Phenytoin | 1 | Related | 9493761 |
| CYP2A6 | Glucuronide | 1 | Related | 11377097 |
| CYP2A6 | Oral contraceptives | 1 | Not Related | 9653923 |
| CYP2A6 | Procainamide | 1 | Related | 9352574 |
| CYP2C19 | Halothane | 1 | No Evidence | |
| CYP2C19 | Steroids | 1 | Related | 7704034 |
| CYP2C9 | Ascorbic acid | 1 | No Evidence | |
| CYP2C9 | Codeine | 1 | Not Related | 9113345 |
| CYP2C9 | Flecainide | 1 | Related | 8801060 |
| CYP2D6 | Hydralazine | 1 | No Evidence | |
| CYP2E1 | Dopamine | 1 | Related | 9881865 |
| CYP3A5 | Aflatoxin | 1 | Related | 10224324 |
| CYP3A7 | Phenytoin | 1 | Related | 9493761 |
| Dihydropyrimidine dehydrogenase | Bilirubin | 1 | Related | 10348793 |
| Dihydropyrimidine dehydrogenase | Glutathione | 1 | No Evidence | |
| DT-diaphorase | Glucuronide | 1 | No Evidence | |
| Glucocorticoid receptor | Menadione | 1 | Related | 11311319 |
| Glucocorticoid receptor | Quinidine | 1 | No Evidence | |
| Glucocorticoid receptor | Tacrolimus | 1 | Related | 9600660 |
| Glutathione S-transferase | Histamine | 1 | Related | 10372823 |
| Glutathione S-transferase | Paclitaxel | 1 | Not Related | 9849488 |
| GSTM1 | Vinyl chloride | 1 | Related | 9838066 |
| GSTP1 | Cyclosporin A | 1 | Related | 11108662 |
| MRP | Benzo(a)pyrene | 1 | No Evidence | |
| MRP | Ethoxyresorufin | 1 | No Evidence | |
| MRP | Naproxen | 1 | Related | 9849488 |
| MRP | Propranolol | 1 | No Evidence | |
| MRP | Tamoxifen | 1 | No Evidence | |
| N-Acetyltransferase | Conjugates | 1 | No Evidence | |
| N-Acetyltransferase | Insulin | 1 | Related | 7017937 |
| N-Acetyltransferase | Vinyl chloride | 1 | Not Related | 1458774 |
| NAT1 | Phenacetin | 1 | Related | 9761125 |
| NAT2 | Irinotecan | 1 | No Evidence | |
| Peroxisome proliferator-activated receptor | Glutathione | 1 | No Evidence | |
| Peroxisome proliferator-activated receptor | Naringenin | 1 | Not Related | 11245597 |
| Prothrombin | p-Aminobenzoic acid | 1 | No Evidence | |
| Stromelysin | Dexamethasone | 1 | No Evidence | |
| Sulfotransferase | Benzo(a)pyrene | 1 | No Evidence | |
| Sulfotransferase | Oral contraceptives | 1 | Related | 6934248 |
| UGT1A1 | Ethanol | 1 | Related | 11091029 |
| Uridine diphosphate-glucuronosyl transferase | Glucuronide | 1 | Related | 9054958 |
| Vitamin D receptor | Tamoxifen | 1 | No Evidence |